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Cabergoline: Side Effects, Dosage, Uses, and More

Cabergoline: Side Effects, Dosage, Uses, and More

In a combination study with 2,000 patients also treated with levodopa, the incidence and severity of side effects was comparable to monotherapy. Encountered side effects required a termination of cabergoline treatment in 15% of patients. Additional side effects were infrequent cases of hematological side effects, and an occasional increase in liver enzymes or serum creatinine without signs or symptoms.

  • To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
  • There are other drugs available to treat your condition.
  • In men, high prolactin levels can affect reproduction and cause sexual issues.
  • If you have an allergic reaction, call your doctor or local poison control center right away.
  • To help avoid interactions, your doctor should manage all of your medications carefully.

A decrease in prolactin levels prevents lactation and provides the disappearance of clinical signs of false pregnancy (pseudopregnancy) in female dogs and cats. As with other ergot derivatives, pleuritis, exudative pleura disease, pleura fibrosis, lung fibrosis, and pericarditis are seen. These side effects are noted in less than 2% of patients. Clinical improvement and normalization of X-ray findings are normally seen soon after cabergoline withdrawal. It appears that the dose typically used for treatment of hyperprolactinemia is too low to cause this type of side effects.

Important considerations for taking this drug

Talk to your doctor about other drug options that may work for you. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills https://www.familychildcareassociation.com/2022/06/30/exploring-the-link-between-clomid-and-steroid-use authorized on your prescription. Call your doctor right away if you become pregnant while taking this drug. Cabergoline oral tablet can cause drowsiness as well as other side effects.


Cabergoline requires slow dose titration (2–4 weeks for hyperprolactinemia, often much longer for other conditions) to minimize side effects. The extremely long bioavailability of the medication may complicate dosing regimens during titration and require particular precautions. Cabergoline, sold under the brand name Dostinex among others, is a dopaminergic medication used in the treatment of high prolactin levels, prolactinomas, Parkinson’s disease, and for other indications.

Following a single oral dose, resorption of cabergoline from the gastrointestinal (GI) tract is highly variable, typically occurring within 0.5 to 4 hours. Human bioavailability has not been determined since the drug is intended for oral use only. In mice and rats the absolute bioavailability has been determined to be 30 and 63 percent, respectively.

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